Carcinogenesis

ACCELERATED PAPER:

Randy L. Jirtle, Gerald R. Hankins, Herbert Reisenbichler, and Ivan J. Boyer

Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital
Carcinogenesis 1994 15: 1473-1478; doi:10.1093/carcin/15.8.1473 [Abstract] [PDF] [Request Permissions]  

Matthew W. Himmelstein, Max J. Turner, Bahman Asgharian, and James A. Bond

Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation
Carcinogenesis 1994 15: 1479-1486; doi:10.1093/carcin/15.8.1479 [Abstract] [PDF] [Request Permissions]  

David H. Phillips, Gerard A. Potter, Martin N. Horton, Alan Hewker, Christopher Crofton-Sleigh, Michael Jarman, and Stanley Venitt

Reduced genotoxicity of [D₅-ethyl]-tamoxifen implicates -hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen
Carcinogenesis 1994 15: 1487-1492; doi:10.1093/carcin/15.8.1487 [Abstract] [PDF] [Request Permissions]  

Maura Mezzina, Eric Eveno, Odile Chevallier-Lagente, Annie Benoit, Madeleine Carreau, Wim Vermeulen, Jan H J. Hoeijmakers, Miria Stefanini, Alan R. Lehmann, Christine A. Weber, and Alain Sarasin

Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells
Carcinogenesis 1994 15: 1493-1498; doi:10.1093/carcin/15.8.1493 [Abstract] [PDF] [Request Permissions]  

H. Tinwell and J. Ashby

Genetic toxicity and potential carcinogenicity of taxol
Carcinogenesis 1994 15: 1499-1501; doi:10.1093/carcin/15.8.1499 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Sara A. Fitzsimmons, Alexander D. Lewis, Robert J. Riley, and Paul Workman

Reduction of 3-amino-l,2,4-benzotriazine-l,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH: cytochrome P450 oxidoreductase
Carcinogenesis 1994 15: 1503-1510; doi:10.1093/carcin/15.8.1503 [Abstract] [PDF] [Request Permissions]  

Maria A.E. Johansson and Margaretha Jägerstad

Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions
Carcinogenesis 1994 15: 1511-1518; doi:10.1093/carcin/15.8.1511 [Abstract] [PDF] [Request Permissions]  

Torn Takeuchi, Madoka Nakajima, Yukinobu Ohta, Kanae Mure, Tatsuya Takeshita, and Kanehisa Morimoto

Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes
Carcinogenesis 1994 15: 1519-1523; doi:10.1093/carcin/15.8.1519 [Abstract] [PDF] [Request Permissions]  

L. Cruzeiro-Hansson and J.M. Goodfellow

Flexibility and curvature of DNA duplexes containing O⁴-methylthymine: implications for DNA repair
Carcinogenesis 1994 15: 1525-1533; doi:10.1093/carcin/15.8.1525 [Abstract] [PDF] [Request Permissions]  

István Drin, Bernadette Schoket, Szilárd Kostic, and Istvan Vincze

Smoking-related increase in O⁶-alkylguanine-DNA alkyltransferase activity in human lung tissue
Carcinogenesis 1994 15: 1535-1539; doi:10.1093/carcin/15.8.1535 [Abstract] [PDF] [Request Permissions]  

M. Mesnil, D. Rideout, N.M. Kumar, and N.B. Gilula

Non-communicating human and murine carcinoma cells produce ₁ gap junction mRNA
Carcinogenesis 1994 15: 1541-1547; doi:10.1093/carcin/15.8.1541 [Abstract] [PDF] [Request Permissions]  

Achim Orzechowski, Dieter Schrenk, Barbara S. Bock-Hennig, and Karl Walter Bock

Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferases of the UGT1 gene complex
Carcinogenesis 1994 15: 1549-1553; doi:10.1093/carcin/15.8.1549 [Abstract] [PDF] [Request Permissions]  

Shigeyuki Sugie, Kiyohisa Okamoto, Ataru Okumura, Takuji Tanaka, and Hideki Mori

Inhibitory effects of benzyl thiocyanate and benzyl isothiocyanate on methylazoxymethanol acetate-induced intestinal carcinogenesis in rats
Carcinogenesis 1994 15: 1555-1560; doi:10.1093/carcin/15.8.1555 [Abstract] [PDF] [Request Permissions]  

Ulla Stenius, Margarets Warholm, Ulf Martens, and Johan Högberg

Isolation of glutathione S-transferase P-positive hepatocytes from carcinogen treated rats by use of ethacrynic acid as selecting agent
Carcinogenesis 1994 15: 1561-1566; doi:10.1093/carcin/15.8.1561 [Abstract] [PDF] [Request Permissions]  

Meenakshi Singh, Junxuan Lu, Stephanie P. Briggs, John N. McGinley, Albert D. Haegele, and Henry J. Thompson

Effect of excess dietary iron on the promotion stage of 1-methyl-1- nitrosourea-induced mammary carcinogenesis: pathogenetic characteristics and distribution of iron
Carcinogenesis 1994 15: 1567-1570; doi:10.1093/carcin/15.8.1567 [Abstract] [PDF] [Request Permissions]  

Jilun Zhang and Luke K.T. Lam

Colonoscopic colostomy model in rats for colon tumorigenesis studies
Carcinogenesis 1994 15: 1571-1576; doi:10.1093/carcin/15.8.1571 [Abstract] [PDF] [Request Permissions]  

E.A. Drobetsky, E. Moustacchi, B. W. Glickman, and E. Sage

The mutational specificity of simulated sunlight at the aprt locus in rodent cells
Carcinogenesis 1994 15: 1577-1583; doi:10.1093/carcin/15.8.1577 [Abstract] [PDF] [Request Permissions]  

Susan J. Land, Richard F Jones, and Charles M. King

Biochemical and genetic analysis of two acetyltransferases from hamster tissues that can metabolize aromatic amine derivatives
Carcinogenesis 1994 15: 1585-1595; doi:10.1093/carcin/15.8.1585 [Abstract] [PDF] [Request Permissions]  

M.Saveria Campo, Brian W. O’Neil, Ronald J. Barron, and William F.H. Jarrett

Experimental reproduction of the papilloma-carcinoma complex of the alimentary canal in cattle
Carcinogenesis 1994 15: 1597-1601; doi:10.1093/carcin/15.8.1597 [Abstract] [PDF] [Request Permissions]  

W. Popp, R. Wolf, C. Vahrenholz, J. Radtke, C. Schell, R. Kraus, A. Brauksiepe, and K. Norpoth

Sister chromatid exchange frequencies in lymphocytes of oral cancer patients seem to be influenced by drinking habits
Carcinogenesis 1994 15: 1603-1607; doi:10.1093/carcin/15.8.1603 [Abstract] [PDF] [Request Permissions]  

Anne Fischer-Nielsen, Inge Bøgh Jeding, and Steffen Loft

Radiation-induced formation of 8-hydroxy-2'-deoxyguanosine and its prevention by scavengers
Carcinogenesis 1994 15: 1609-1612; doi:10.1093/carcin/15.8.1609 [Abstract] [PDF] [Request Permissions]  

B.A. Ruggeri, B. Bauer, S.-Y. Zhang, and A.J.P. Klein-Szanto

Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities
Carcinogenesis 1994 15: 1613-1619; doi:10.1093/carcin/15.8.1613 [Abstract] [PDF] [Request Permissions]  

Pierre Tachon, Andrée Deflandre, and Paolo U. Giacomoni

Modulation by L-histidine of H₂O₂-mediated damage of cellular and isolated DNA
Carcinogenesis 1994 15: 1621-1626; doi:10.1093/carcin/15.8.1621 [Abstract] [PDF] [Request Permissions]  

M.Said Ahmed, K. Ainley, J.H. Parish, and S.M. Had

Free radical-induced fragmentation of proteins by quercetin
Carcinogenesis 1994 15: 1627-1630; doi:10.1093/carcin/15.8.1627 [Abstract] [PDF] [Request Permissions]  

Juan Segura-Aguilar, Antonio Cremades, Antonio Llombart-Bosch, Elena Monsalve, Lars Ernster, and Francisco J. Romero

Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours
Carcinogenesis 1994 15: 1631-1636; doi:10.1093/carcin/15.8.1631 [Abstract] [PDF] [Request Permissions]  

Lisa M. Davis, William J. Caspary, Sameer A. Sakallah, Robert Maronpot, Roger Wiseman, J.Carl Barrett, Rosemary Elliott, and John C. Hozier

Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse
Carcinogenesis 1994 15: 1637-1645; doi:10.1093/carcin/15.8.1637 [Abstract] [PDF] [Request Permissions]  

R. Rita Misra, Su-Yin Chiang, and James A. Swenberg

A comparison of two ultrasensitive methods for measuring 1,N⁶-etheno-2'- deoxyadenosine and 3,N⁴-etheno-2'-deoxycytidine in cellular DNA
Carcinogenesis 1994 15: 1647-1652; doi:10.1093/carcin/15.8.1647 [Abstract] [PDF] [Request Permissions]  

Ying Huang, Jing Yin, and Stephen J. Meltzer

A unique p53 intragenic deletion flanked by short direct repeats results in loss ofmRNA expression in a human esophageal carcinoma
Carcinogenesis 1994 15: 1653-1655; doi:10.1093/carcin/15.8.1653 [Abstract] [PDF] [Request Permissions]  

Ih-Chang Hsu, QiuPing Yang, Myong W. Kahng, and Jing-Fan Xu

Detection of DNA point mutations with DNA mismatch repair enzymes
Carcinogenesis 1994 15: 1657-1662; doi:10.1093/carcin/15.8.1657 [Abstract] [PDF] [Request Permissions]  

Takahiro Ogawa, Takao Makino, Nobuaki Hirose, and Michihiro Sugano

Lack of influence of low blood cholesterol levels on pancreatic carcinogenesis after initiation with N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters
Carcinogenesis 1994 15: 1663-1666; doi:10.1093/carcin/15.8.1663 [Abstract] [PDF] [Request Permissions]  

Amita Grover-Bardwick, Eileen Adamson, and Dan Mercola

Transformation-specific pattern of phosphorylation of c-Jun, Jun-B, Jun-D and Egr-1 in v-sis transformed cells
Carcinogenesis 1994 15: 1667-1674; doi:10.1093/carcin/15.8.1667 [Abstract] [PDF] [Request Permissions]  

Vassilis L. Souliotis, Christos Valavanis, Viki A. Boussiotis, Gerasimos A. Pangalis, and Soterios A. Kyrtopoulos

Comparative dosimetry of O⁶-methylguanine in humans and rodents treated with procarbazine
Carcinogenesis 1994 15: 1675-1680; doi:10.1093/carcin/15.8.1675 [Abstract] [PDF] [Request Permissions]  

Christos Valavanis, Vassilis L. Souliotis, and Soterios A. Kyrtopoulos

Differential effects of procarbazine and methylnitrosourea on the accumulation of O⁶-methylguanine and the depletion and recovery of O⁶-alkylguanine-DNA alkyltransferase in rat tissues
Carcinogenesis 1994 15: 1681-1688; doi:10.1093/carcin/15.8.1681 [Abstract] [PDF] [Request Permissions]  

Satoshi Tanno and Katsuhiro Ogawa

Abundant TGF a precursor and EGF receptor expression as a possible mechanism for the preferential growth of carcinogeninduced preneoplastic and neoplastic hepatocytes in rats
Carcinogenesis 1994 15: 1689-1694; doi:10.1093/carcin/15.8.1689 [Abstract] [PDF] [Request Permissions]  

Keith R. Kaderlik, Gerard J. Mulder, Robert J. Turesky, Nicholas P. Lang, Candee H. Teitel, M.Paul Chiarelli, and Fred F. Kadlubar

Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes
Carcinogenesis 1994 15: 1695-1701; doi:10.1093/carcin/15.8.1695 [Abstract] [PDF] [Request Permissions]  

Keith R. Kaderlik, Rodney F. Minchin, Gerard J. Mulder, Kenneth F. Ilett, Maria Daugaard-Jenson, Candee H. Teitel, and Fred F. Kadlubar

Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-l-methyl-6-phenyUmidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues
Carcinogenesis 1994 15: 1703-1709; doi:10.1093/carcin/15.8.1703 [Abstract] [PDF] [Request Permissions]  

Keith R. Kaderlik, Gerard J. Mulder, Joseph G. Shaddock, Daniel A. Casciano, Candee H. Teitel, and Fred F. Kadlubar

Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP–DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes
Carcinogenesis 1994 15: 1711-1716; doi:10.1093/carcin/15.8.1711 [Abstract] [PDF] [Request Permissions]  

Jen-Kun Lin and Cheng-An Shih

Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NJH3T3 cells
Carcinogenesis 1994 15: 1717-1721; doi:10.1093/carcin/15.8.1717 [Abstract] [PDF] [Request Permissions]  

Kersi B. Vasunia, Marian L. Miller, Stacey Andringa, and C.Stuart Baxter

Induction of interleukin-6 in the epidermis of mice in response to tumor-promoting agents
Carcinogenesis 1994 15: 1723-1727; doi:10.1093/carcin/15.8.1723 [Abstract] [PDF] [Request Permissions]  

S.-J.C. Wei, R. L. Chang, E. Hennig, X.X. Cui, K.A. Merkler, C.-Q. Wong, H. Yagi, D.M. Jerina, and A.H. Conney

Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,10-epoxide enantiomers with high and low carcinogenic activity
Carcinogenesis 1994 15: 1729-1735; doi:10.1093/carcin/15.8.1729 [Abstract] [PDF] [Request Permissions]  

Fu-Li Yu, Wanda Bender, and Alan Hutchcroft

Studies on the binding and transcriptional properties of aflatoxin B₁-8,9-epoxide
Carcinogenesis 1994 15: 1737-1741; doi:10.1093/carcin/15.8.1737 [Abstract] [PDF] [Request Permissions]  

SHORT COMMUNICATION:

Caterina A.M.La Porta and Roberto Comolli

Membrane and nuclear protein kinase C activation in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis
Carcinogenesis 1994 15: 1743-1747; doi:10.1093/carcin/15.8.1743 [Abstract] [PDF] [Request Permissions]  

Stephen P. Faux, Peter J. Howden, and Leonard S. Levy

Iron-dependent formation of 8-hydroxydeoxyguanosine in isolated DNA and mutagenicity in Salmonella typhimurium TA102 induced by crocidolite
Carcinogenesis 1994 15: 1749-1751; doi:10.1093/carcin/15.8.1749 [Abstract] [PDF] [Request Permissions]  

Ann P. Kwiatkowski, Thomas K. Baker, and James E. Klaunig

Comparison of glucocorticoid-mediated changes in the expression and function of rat hepatocyte gap junctional proteins
Carcinogenesis 1994 15: 1753-1757; doi:10.1093/carcin/15.8.1753 [Abstract] [PDF] [Request Permissions]  

Toshiya Suzuki, Masayoshi Imagawa, Ryutaro Yamada, Kazushige Yokoyama, Shinichi Kondo, Keiichi Itakura, and Masami Muramatsu

Acute changes in liver gene expression in the N-nitrosodiethylamine-treated rat
Carcinogenesis 1994 15: 1759-1761; doi:10.1093/carcin/15.8.1759 [Abstract] [PDF] [Request Permissions]  

Russell C. Cattley, Michiyuki Kato, James A. Popp, Vonda J. Teets, and Karin S. Voss

Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate
Carcinogenesis 1994 15: 1763-1766; doi:10.1093/carcin/15.8.1763 [Abstract] [PDF] [Request Permissions]  

Erratum:

A. Hirvonen, L. Nylund, P. Kochiba, K. Husgafvel-Pursiainen, and H. Vainio

Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers
Carcinogenesis 1994 15: 1767; doi:10.1093/carcin/15.8.1767 [Abstract] [PDF] [Request Permissions]  

Announcement:

Chemical Mixtures and Quantitative Risk Assessment
Carcinogenesis 1994 15: 1767; doi:10.1093/carcin/15.8.1767-a [PDF] [Request Permissions]  

Author index:

Author index
Carcinogenesis 1994 15: 1768; doi:10.1093/carcin/15.8.1768 [PDF] [Request Permissions]  

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