Carcinogenesis

ACCELERATED PAPER:

Masoud Yadollahi-Farsani, Nigel J. Gooderham, Donald S. Davies, and Alan R. Boobis

ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus
Carcinogenesis 1996 17: 617-624; doi:10.1093/carcin/17.4.617 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES: CANCER BIOLOGY:

Dian Wang, Christopher M. Weghorst, Richard J. Calvert, and Gary D. Stoner

Mutations in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine
Carcinogenesis 1996 17: 625-630; doi:10.1093/carcin/17.4.625 [Abstract] [PDF] [Request Permissions]  

James R. Jacob and Bud C. Tennant

Transformation of immortalized woodchuck hepatic cell lines with the c-Ha-ras proto-oncogene
Carcinogenesis 1996 17: 631-636; doi:10.1093/carcin/17.4.631 [Abstract] [PDF] [Request Permissions]  

S.M. Lee, H. Reid, R.H. Elder, N. Thatcher, and G.P. Margison

Inter- and intracellular heterogeneity of O⁶-alkylguanine-DNA alkyltransferase expression in human brain tumours: possible significance in nitrosourea therapy
Carcinogenesis 1996 17: 637-641; doi:10.1093/carcin/17.4.637 [Abstract] [PDF] [Request Permissions]  

William B. Mattes, Chong-Soon Lee, Jacques Laval, and Timothy R. O'Connor

Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases
Carcinogenesis 1996 17: 643-648; doi:10.1093/carcin/17.4.643 [Abstract] [PDF] [Request Permissions]  

Katherine A. Vallis and C. Roland WOlf

Relationship between the adaptive response to oxidants and stable menadione-resistance in Chinese hamster ovary cell lines
Carcinogenesis 1996 17: 649-654; doi:10.1093/carcin/17.4.649 [Abstract] [PDF] [Request Permissions]  

Simon D. Bouffler, George Breckon, and Roger Cox

Chromosomal mechanisms in murine radiation acute myeloid leukaemogenesis
Carcinogenesis 1996 17: 655-659; doi:10.1093/carcin/17.4.655 [Abstract] [PDF] [Request Permissions]  

Keiji Suzuki and Tom K. Hei

Induction of heme oxygenase in mammalian cells by mineral fibers: distinctive effect of reactive oxygen species
Carcinogenesis 1996 17: 661-667; doi:10.1093/carcin/17.4.661 [Abstract] [PDF] [Request Permissions]  

Sujatha G. Sundaram and John A. Milner

Diallyl disulfide induces apoptosis of human colon tumor cells
Carcinogenesis 1996 17: 669-673; doi:10.1093/carcin/17.4.669 [Abstract] [PDF] [Request Permissions]  

K.C. Jamison, J.L. Larson, B.E. Butterworth, R. Harden, B.L. Skinner, and D.C. Wolf

A non-bile duct origin for intestinal crypt-like ducts with periductular fibrosis induced in livers of F344 rats by chloroform inhalation
Carcinogenesis 1996 17: 675-682; doi:10.1093/carcin/17.4.675 [Abstract] [PDF] [Request Permissions]  

Gavin Brooks, Susan F. Brooks, and Martin W. Goss

MARCKS functions as a novel growth suppressor in cells of melanocyte origin
Carcinogenesis 1996 17: 683-689; doi:10.1093/carcin/17.4.683 [Abstract] [PDF] [Request Permissions]  

Razmik Mirzayans, Louise Enns, Kevin Dietrich, Randy D.C. Barley, and Malcolm C. Paterson

Faculty DNA polymerase /-mediated excision repair in response to radiation or ultraviolet light in p53-deficient fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome
Carcinogenesis 1996 17: 691-698; doi:10.1093/carcin/17.4.691 [Abstract] [PDF] [Request Permissions]  

David T. Lowry, Luowei Li, and Henry Hennings

Thapsigargin, a weak skin tumor promoter, alters the growth and differentiation of mouse keratinocytes in culture
Carcinogenesis 1996 17: 699-706; doi:10.1093/carcin/17.4.699 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES: MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION:

D.K. Scates, A.D. Spigelman, R.K.S. Phillips, and S. Venitt

Differences in the levels and pattern of DNA-adduct labelling in human cell lines MCL-5 and CCRF, proficient or deficient in carcinogen-metabolism, treated in vitro with bile from familial adenomatous polyposis patients and from unaffected controls
Carcinogenesis 1996 17: 707-713; doi:10.1093/carcin/17.4.707 [Abstract] [PDF] [Request Permissions]  

Jan P.G. Brakenhoff, Jan N.M. Commandeur, Lars W. Wormhoudt, Ed J. Groot, and Nico P.E. Vermeulen

Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions
Carcinogenesis 1996 17: 715-724; doi:10.1093/carcin/17.4.715 [Abstract] [PDF] [Request Permissions]  

Vassilis L. Souliotis, Christos Valavanis, Viki A. Boussiotis, Gerasimos A. Pangalis, and Soterios A. Kyrtopoulos

Comparative study of the formation and repair of O⁶-methylguanine in humans and rodents treated with dacarbazine
Carcinogenesis 1996 17: 725-732; doi:10.1093/carcin/17.4.725 [Abstract] [PDF] [Request Permissions]  

Philip Lazarus, Jordan Stern, Neil Zwiebel, Alex Fair, John P. Richie, Jr., and Stimson Schantz

Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use
Carcinogenesis 1996 17: 733-739; doi:10.1093/carcin/17.4.733 [Abstract] [PDF] [Request Permissions]  

Brunhilde Blömeke, Michael J. Greenblatt, D. Van Doan, Elise D. Bowman, Sharon E. Murphy, Clara C. Chen, Shunji Kato, and Peter G. Shields

Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung
Carcinogenesis 1996 17: 741-748; doi:10.1093/carcin/17.4.741 [Abstract] [PDF] [Request Permissions]  

Bogdan Prokopczyk, Jonathan E. Cox, Pramod Upadhyaya, Shantu Amin, Dhimant Desai, Dietrich Hoffmann, and Karam El-Bayoumy

Effects of dietary 1,4-phenylenbis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats
Carcinogenesis 1996 17: 749-753; doi:10.1093/carcin/17.4.749 [Abstract] [PDF] [Request Permissions]  

Ding Jiao, Theresa J. Smith, Sungbin Kim, Chung S. Yang, Dhimant Desai, Shantu Amin, and Fung-Lung Chung

The essential role of the functional group in alkyl isothiocyanates for inhibition of tobacco nitrosamine-induced lung tumorigenesis
Carcinogenesis 1996 17: 755-759; doi:10.1093/carcin/17.4.755 [Abstract] [PDF] [Request Permissions]  

Mou-Tuan Huang, Wei Ma, Patricia Yen, Jian-Guo Xie, Jingkang Han, Krystyna Frenkel, Dezider Grunberger, and Allan H. Conney

Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells
Carcinogenesis 1996 17: 761-765; doi:10.1093/carcin/17.4.761 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES: CARCINOGENESIS:

Kenzo Yamanaka, Kaori Ohtsubo, Akira Hasegawa, Hiroyuki Hayashi, Hiroshi Ohji, Masayoshi Kanisawa, and Shoji Okada

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice
Carcinogenesis 1996 17: 767-770; doi:10.1093/carcin/17.4.767 [Abstract] [PDF] [Request Permissions]  

Laurie Brennan and Jan Jongstra

Low expression of the Lsp1 gene in early mouse T-lymphomas induced by N-methyl-N-nitrosourea
Carcinogenesis 1996 17: 771-777; doi:10.1093/carcin/17.4.771 [Abstract] [PDF] [Request Permissions]  

C. J.T. Visser, A.H. Bruggink, M. Korc, M.S. Kobrin, R.A. de Weger, I. Seifert-Bock, W.T.M. van Blokland, A. van Garderen-Hoetmer, and R.A. Woutersen

Overexpression of transforming growth factor- and epidermal growth factor receptor, but not epidermal growth factor, in exocrine pancreatic tumours in hamsters
Carcinogenesis 1996 17: 779-785; doi:10.1093/carcin/17.4.779 [Abstract] [PDF] [Request Permissions]  

Madoka Nakajima, Toru Takeuchi, and Kanehisa Morimoto

Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions
Carcinogenesis 1996 17: 787-791; doi:10.1093/carcin/17.4.787 [Abstract] [PDF] [Request Permissions]  

Morten A. Kall, Ole Vang, and JØrgen Clausen

Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism
Carcinogenesis 1996 17: 793-799; doi:10.1093/carcin/17.4.793 [Abstract] [PDF] [Request Permissions]  

Pavel Vodicka, Rudolf Stetina, Rajiv Kumar, Kamila Plna, and Kari Hemminki

7-Alkylguanine adducts of styrene oxide determined by ³²P-postlabelling in DNA and human embryonal lung fibroblasts (HEL)
Carcinogenesis 1996 17: 801-808; doi:10.1093/carcin/17.4.801 [Abstract] [PDF] [Request Permissions]  

Theresa J. Smith, Zuyu Guo, F.Peter Guengerich, and Chung S. Yang

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate
Carcinogenesis 1996 17: 809-813; doi:10.1093/carcin/17.4.809 [Abstract] [PDF] [Request Permissions]  

Min-Liang Kuo, Tzu-Ching Meng, and Jen-Kun Lin

Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells
Carcinogenesis 1996 17: 815-820; doi:10.1093/carcin/17.4.815 [Abstract] [PDF] [Request Permissions]  

Dean Ahn, David Putt, Laura Kresty, Gary D. Stoner, David Fromm, and Paul F. Hollenberg

The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes
Carcinogenesis 1996 17: 821-828; doi:10.1093/carcin/17.4.821 [Abstract] [PDF] [Request Permissions]  

F. Ariese, G.J. Small, and R. Jankowiak

Conformational studies of depurinating DNA adducts from syn-dibenzo(a,l)pyrene diolepoxide
Carcinogenesis 1996 17: 829-837; doi:10.1093/carcin/17.4.829 [Abstract] [PDF] [Request Permissions]  

Liming Shu and Paul F. Hollenberg

Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-, N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine
Carcinogenesis 1996 17: 839-848; doi:10.1093/carcin/17.4.839 [Abstract] [PDF] [Request Permissions]  

Ronald E. Bishop, Gary T. Pauly, and Robert C. Moschel

O⁶-Ethylguanine and O⁶-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells
Carcinogenesis 1996 17: 849-856; doi:10.1093/carcin/17.4.849 [Abstract] [PDF] [Request Permissions]  

Santhanam Swaminathan, Susan M. Frederickson, James F. Hatcher, Catherine A. Reznikoff, Mary A. Butler, Kenneth L. Cheever, and Russell E. Savage, Jr

Neoplastic transformation and DNA-binding of 4, 4'-methylenebis (2-chloroaniline) in SV40-immortalized human uroepithelial cell lines
Carcinogenesis 1996 17: 857-864; doi:10.1093/carcin/17.4.857 [Abstract] [PDF] [Request Permissions]  

David Warshawsky, Glenn Talaska, Marlene Jaeger, Tyrone Collins, Anthony Galati, Liang You, and Gary Stoner

Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c, g]carbazole in strain A/J mouse lung
Carcinogenesis 1996 17: 865-871; doi:10.1093/carcin/17.4.865 [Abstract] [PDF] [Request Permissions]  

SHORT COMMUNICATIONS:

Yi Jin, Fredric J. Burns, Seymour J. Garte, and Steve Hosselet

SHORT COMMUNICATION: Infrequent alterations of the p53 gene in rat skin cancers induced by ionizing radiation
Carcinogenesis 1996 17: 873-876; doi:10.1093/carcin/17.4.873 [Abstract] [PDF] [Request Permissions]  

S. Balasubramanian and S. Govindasamy

SHORT COMMUNICATION: Inhibitory effect of dietary flavonol quercetin on 7,12-dimethyl-benz[]anthracene-induced hamster buccal pouch carcinogenesis
Carcinogenesis 1996 17: 877-879; doi:10.1093/carcin/17.4.877 [Abstract] [PDF] [Request Permissions]  

Mark Deakin, James Elder, Charles Hendrickkse, Daniel Peckham, David Leopard, Douglas A. Bell, Peter Jones, Hamish Duncan, Kate Brannigan, Julie Alldersea, Anthony A. Fryer, and Richard C. Strange

SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers
Carcinogenesis 1996 17: 881-884; doi:10.1093/carcin/17.4.881 [Abstract] [PDF] [Request Permissions]  

Piero Sestili, Andrea Guidarelli, Flaminio Cattabeni, David Murray, and Orazio Cantoni

SHORT COMMUNICATION: AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine
Carcinogenesis 1996 17: 885-888; doi:10.1093/carcin/17.4.885 [Abstract] [PDF] [Request Permissions]  

N.J. Butcher, R.F. Minchin, F.F. Kadlubar, and K.F. llett

SHORT COMMUNICATION: Uptake of the food-derived heterocyclic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine and its N-hydroxy metabolite into rat pancreatic acini and hepatocytes in vitro
Carcinogenesis 1996 17: 889-892; doi:10.1093/carcin/17.4.889 [Abstract] [PDF] [Request Permissions]  

Erratum:

Erratum
Carcinogenesis 1996 17: 892; doi:10.1093/carcin/17.4.892 [Abstract] [PDF] [Request Permissions]  

Announcements:

Announcements
Carcinogenesis 1996 17: 893; doi:10.1093/carcin/17.4.893 [PDF] [Request Permissions]  

Author index:

Author index
Carcinogenesis 1996 17: 894; doi:10.1093/carcin/17.4.894 [PDF] [Request Permissions]  

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