Carcinogenesis

COMMENTARY:

John D. Groopman and Thomas W. Kensler

The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight?
Carcinogenesis 1999 20: 1-11; doi:10.1093/carcin/20.1.1 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

CANCER BIOLOGY:

Jae-Ho Yang, Christoph Vogel, and Josef Abel

A malignant transformation of human cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits altered expressions of growth regulatory factors
Carcinogenesis 1999 20: 13-18; doi:10.1093/carcin/20.1.13 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Murray A. Francis and Andrew J. Rainbow

UV-enhanced reactivation of a UV-damaged reporter gene suggests transcription-coupled repair is UV-inducible in human cells
Carcinogenesis 1999 20: 19-26; doi:10.1093/carcin/20.1.19 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michelle L. Rose, Chantal A. Rivera, Blair U. Bradford, Lee M. Graves, Russell C. Cattley, Robert Schoonhoven, James A. Swenberg, and Ronald G. Thurman

Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators
Carcinogenesis 1999 20: 27-33; doi:10.1093/carcin/20.1.27 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Margaret M. Lehane, Peter E. Bryant, Andrew C. Riches, Louise A. Allen, Cecilie V. Briscoe, Jean Melville, and Andrew J. Mill

²³⁸Pu -particle-induced C3H10T½ transformants are less tumorigenic than the X-ray-induced equivalent
Carcinogenesis 1999 20: 35-40; doi:10.1093/carcin/20.1.35 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sean Sanders and Snorri S. Thorgeirsson

Phenobarbital promotes liver growth in c-myc/TGF- transgenic mice by inducing hypertrophy and inhibiting apoptosis
Carcinogenesis 1999 20: 41-49; doi:10.1093/carcin/20.1.41 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION:

Steve R. Ritland and Sandra J. Gendler

Chemoprevention of intestinal adenomas in the Apc^Min mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression
Carcinogenesis 1999 20: 51-58; doi:10.1093/carcin/20.1.51 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Goshi Shiota, Ken-ichi Harada, Masato Ishida, Yasushi Tomie, Michiko Okubo, Shunsuke Katayama, Hisao Ito, and Hironaka Kawasaki

Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice
Carcinogenesis 1999 20: 59-63; doi:10.1093/carcin/20.1.59 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael P. Waalkes and Bhalchandra A. Diwan

Cadmium-induced inhibition of the growth and metastasis of human lung carcinoma xenografts: role of apoptosis
Carcinogenesis 1999 20: 65-70; doi:10.1093/carcin/20.1.65 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cristina Rodríguez-Burford, Ronald A. Lubet, Isao Eto, M. Margaret Juliana, Gary J. Kelloff, Clinton J. Grubbs, and Vernon E. Steele

Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model
Carcinogenesis 1999 20: 71-76; doi:10.1093/carcin/20.1.71 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Eric Poe Xing, Yan Nie, Li-Dong Wang, Guang-Yu Yang, and Chung S. Yang

Aberrant methylation of p16^INK4a and deletion of p15^INK4b are frequent events in human esophageal cancer in Linxian, China
Carcinogenesis 1999 20: 77-84; doi:10.1093/carcin/20.1.77 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard E. Kozack and Edward L. Loechler

Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N²-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis
Carcinogenesis 1999 20: 85-94; doi:10.1093/carcin/20.1.85 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard E. Kozack, Rajiv Shukla, and Edward L. Loechler

A hypothesis for what conformation of the major adduct of (+)-anti-B[a]PDE (N²-dG) causes GT versus GA mutations based upon a correlation between mutagenesis and molecular modeling results
Carcinogenesis 1999 20: 95-102; doi:10.1093/carcin/20.1.95 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Suvarchala Edara, Sreenivas Kanugula, and Anthony E. Pegg

Expression of the inactive C145A mutant human O⁶-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine
Carcinogenesis 1999 20: 103-108; doi:10.1093/carcin/20.1.103 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Roger A. Brooks, Nigel J. Gooderham, Robert J. Edwards, Alan R. Boobis, and Douglas J. Winton

The mutagenicity of benzo[a]pyrene in mouse small intestine
Carcinogenesis 1999 20: 109-114; doi:10.1093/carcin/20.1.109 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kavita Ramamoorthy, Mona Sethi Gupta, Gulan Sun, Andrew McDougal, and Stephen H. Safe

3,3',4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells
Carcinogenesis 1999 20: 115-123; doi:10.1093/carcin/20.1.115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Françoise Tombolan, Dominique Renault, Dominique Brault, Magali Guffroy, Odette Périn-Roussel, François Périn, and Véronique Thybaud

Kinetics of induction of DNA adducts, cell proliferation and gene mutations in the liver of Muta(TM)Mice treated with 5,9-dimethyldibenzo[c,g]carbazole
Carcinogenesis 1999 20: 125-132; doi:10.1093/carcin/20.1.125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eugene J. Mitacek, Klaus D. Brunnemann, Dietrich Hoffmann, Thira Limsila, Maitree Suttajit, Nimit Martin, and Lee S. Caplan

Volatile nitrosamines and tobacco-specific nitrosamines in the smoke of Thai cigarettes: a risk factor for lung cancer and a suspected risk factor for liver cancer in Thailand
Carcinogenesis 1999 20: 133-137; doi:10.1093/carcin/20.1.133 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Harumi Jyonouchi, Sining Sun, Koji Iijima, Mingyao Wang, and Stephen S. Hecht

Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol
Carcinogenesis 1999 20: 139-145; doi:10.1093/carcin/20.1.139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert W. Murray, Megh Singh, and Nigam P. Rath

Arene dioxides of substituted pyrenes: synthesis and X-ray structural studies
Carcinogenesis 1999 20: 147-152; doi:10.1093/carcin/20.1.147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David J. Boocock, James L. Maggs, Ian N.H. White, and B. Kevin Park

-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro
Carcinogenesis 1999 20: 153-160; doi:10.1093/carcin/20.1.153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Masaru Sekijima, Tomoaki Tsutsumi, Toshinori Yoshida, Takanori Harada, Fumio Tashiro, Gang Chen, Shun-Zhang Yu, and Yoshio Ueno

Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B₁-initiated rats
Carcinogenesis 1999 20: 161-165; doi:10.1093/carcin/20.1.161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Cecilia Torres, Chamakura V. Varaprasad, Francis Johnson, and Charles R. Iden

Formation of s-triazines during aerial oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in concentrated ammonia
Carcinogenesis 1999 20: 167-172; doi:10.1093/carcin/20.1.167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SHORT COMMUNICATIONS:

Kunitoshi Mitsumori, Hiroshi Onodera, Masakazu Takahashi, Takushi Funakoshi, Toru Tamura, Kazuo Yasuhara, Kiyoshi Takegawa, and Michihito Takahashi

Promoting effects of kojic acid due to serum TSH elevation resulting from reduced serum thyroid hormone levels on development of thyroid proliferative lesions in rats initiated with N-bis(2-hydroxypropyl)nitrosamine
Carcinogenesis 1999 20: 173-176; doi:10.1093/carcin/20.1.173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Françoise Dantzer, Josiane Ménissier-de Murcia, Carrolee Barlow, Anthony Wynshaw-Boris, and Gilbert de Murcia

Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice
Carcinogenesis 1999 20: 177-180; doi:10.1093/carcin/20.1.177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Ulla Stenius, Johan Högberg, and P. Duerksen-Hughes

Re: Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117–1125.
Carcinogenesis 1999 20: 181-182; doi:10.1093/carcin/20.1.181 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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