Carcinogenesis

REVIEWS:

Howard E. Ganther

Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase
Carcinogenesis 1999 20: 1657-1666; doi:10.1093/carcin/20.9.1657 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ACCELERATED PAPER:

Xiusheng Qin, Hang Zhou, Lili Liu, and Stanton L. Gerson

Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis
Carcinogenesis 1999 20: 1667-1673; doi:10.1093/carcin/20.9.1667 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CANCER BIOLOGY:

I. Pérez de Castro, M. Malumbres, J. Santos, A. Pellicer, and J. Fernández-Piqueras

Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas
Carcinogenesis 1999 20: 1675-1682; doi:10.1093/carcin/20.9.1675 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eric Pinelli, Nathalie Poux, Liliane Garren, Bernard Pipy, Marcel Castegnaro, David J. Miller, and Annie Pfohl-Leszkowicz

Activation of mitogen-activated protein kinase by fumonisin B₁ stimulates cPLA₂ phosphorylation, the arachidonic acid cascade and cAMP production
Carcinogenesis 1999 20: 1683-1688; doi:10.1093/carcin/20.9.1683 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shu-Jing Caroline Wei, Richard L. Chang, Kathleen A. Merkler, Mark Gwynne, Xiao Xing Cui, Bindu Murthy, Mou-Tuan Huang, Jian-Guo Xie, Yao-Ping Lu, You-Rong Lou, Donald M. Jerina, and Allan H. Conney

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene
Carcinogenesis 1999 20: 1689-1696; doi:10.1093/carcin/20.9.1689 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chyi Chia R. Lee, Toshio Ichihara, Shinji Yamamoto, Hideki Wanibuchi, Kazunobu Sugimura, Seiji Wada, Taketoshi Kishimoto, and Shoji Fukushima

Reduced expression of the CDK inhibitor p27^KIP1 in rat two-stage bladder carcinogenesis and its association with expression profiles of p21^WAF1/Cip1 and p53
Carcinogenesis 1999 20: 1697-1708; doi:10.1093/carcin/20.9.1697 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven H. Erdman, Natalia A. Ignatenko, Marianne B. Powell, Karen A. Blohm-Mangone, Hana Holubec, José M. Guillén-Rodriguez, and Eugene W. Gerner

APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse
Carcinogenesis 1999 20: 1709-1713; doi:10.1093/carcin/20.9.1709 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sharon G. Bonnette, Frances S. Kittrell, L.Clifton Stephens, Raymond E. Meyn, and Daniel Medina

Interactions of apoptosis, proliferation and host age in the regression of the mouse mammary preneoplasia, TM3, carrying an unusual mutation in p53
Carcinogenesis 1999 20: 1715-1720; doi:10.1093/carcin/20.9.1715 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION:

Zongjian Zhu, Weiqin Jiang, and Henry J. Thompson

Effect of energy restriction on tissue size regulation during chemically induced mammary carcinogenesis
Carcinogenesis 1999 20: 1721-1726; doi:10.1093/carcin/20.9.1721 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ruth M. Lunn, Douglas A. Bell, James L. Mohler, and Jack A. Taylor

Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2)
Carcinogenesis 1999 20: 1727-1731; doi:10.1093/carcin/20.9.1727 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tsuyoshi Yamashita, Yuji Yaginuma, Yuji Saitoh, Kiitirou Kawai, Toshiyuki Kurakane, Hiroaki Hayashi, and Mutsuo Ishikawa

Codon 72 polymorphism of p53 as a risk factor for patients with human papillomavirus-associated squamous intraepithelial lesions and invasive cancer of the uterine cervix
Carcinogenesis 1999 20: 1733-1736; doi:10.1093/carcin/20.9.1733 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jifu Zhao, Jiannong Wang, Yingjie Chen, and Rajesh Agarwal

Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation–promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent
Carcinogenesis 1999 20: 1737-1745; doi:10.1093/carcin/20.9.1737 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Marianne Broome Powell, Paul R. Gause, Paul Hyman, Jacalyn Gregus, Maria Lluria-Prevatt, Ray Nagle, and G. Tim Bowden

Induction of melanoma in TPras transgenic mice
Carcinogenesis 1999 20: 1747-1753; doi:10.1093/carcin/20.9.1747 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Raisa Serpi, Johanna Piispala, Matti Järvilehto, and Kirsi Vähäkangas

Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene–DNA adducts as TPA in mouse skin
Carcinogenesis 1999 20: 1755-1760; doi:10.1093/carcin/20.9.1755 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sushil Kumar and Arne Holmgren

Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters
Carcinogenesis 1999 20: 1761-1767; doi:10.1093/carcin/20.9.1761 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Q. Yang, M. Hergenhahn, A. Weninger, and H. Bartsch

Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji
Carcinogenesis 1999 20: 1769-1775; doi:10.1093/carcin/20.9.1769 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wolfram Engst, Robert Landsiedel, Heino Hermersdörfer, Johannes Doehmer, and Hansruedi Glatt

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells
Carcinogenesis 1999 20: 1777-1785; doi:10.1093/carcin/20.9.1777 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kuen-Yuh Wu, Asoka Ranasinghe, Patricia B. Upton, Vernon E. Walker, and James A. Swenberg

Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents
Carcinogenesis 1999 20: 1787-1792; doi:10.1093/carcin/20.9.1787 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xu Lin, David A. Levitsky, John M. King, and T. Colin Campbell

The promotion effect of anorectic drugs on aflatoxin B₁-induced hepatic preneoplastic foci
Carcinogenesis 1999 20: 1793-1799; doi:10.1093/carcin/20.9.1793 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xiaoxin Chen, Guang-yu Yang, Wei Yu Ding, Flordeliza Bondoc, Stephen K. Curtis, and Chung S. Yang

An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload
Carcinogenesis 1999 20: 1801-1808; doi:10.1093/carcin/20.9.1801 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Graeme B.J. Smith, Andre Castonguay, Patty J. Donnelly, Ken R. Reid, Dimitri Petsikas, and Thomas E. Massey

Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells
Carcinogenesis 1999 20: 1809-1818; doi:10.1093/carcin/20.9.1809 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Konstantin Salnikow, Won G. An, Giovanni Melillo, Mikhail V. Blagosklonny, and Max Costa

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
Carcinogenesis 1999 20: 1819-1823; doi:10.1093/carcin/20.9.1819 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shioko Kimura, Mayumi Kawabe, Jerrold M. Ward, Hideki Morishima, Fred F. Kadlubar, George J. Hammons, Pedro Fernandez-Salguero, and Frank J. Gonzalez

CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice
Carcinogenesis 1999 20: 1825-1830; doi:10.1093/carcin/20.9.1825 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Janet C.L. Tou and Lilian U. Thompson

Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures
Carcinogenesis 1999 20: 1831-1835; doi:10.1093/carcin/20.9.1831 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David M. Owens, S.-J. Caroline Wei, and Robert C. Smart

A multihit, multistage model of chemical carcinogenesis
Carcinogenesis 1999 20: 1837-1844; doi:10.1093/carcin/20.9.1837 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel W. Brois, Laura W. McMahon, Nydia I. Ramos, Lynn M. Anglin, Christopher E. Walsh, and Muriel W. Lambert

A deficiency in a 230 kDa DNA repair protein in Fanconi anemia complementation group A cells is corrected by the FANCA cDNA
Carcinogenesis 1999 20: 1845-1853; doi:10.1093/carcin/20.9.1845 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. O'Driscoll, P. Macpherson, Yao-Zhong Xu, and P. Karran

The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells
Carcinogenesis 1999 20: 1855-1862; doi:10.1093/carcin/20.9.1855 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephan Hollenbach, Andreia Dhénaut, Inge Eckert, J. Pablo Radicella, and Bernd Epe

Overexpression of Ogg1 in mammalian cells: effects on induced and spontaneous oxidative DNA damage and mutagenesis
Carcinogenesis 1999 20: 1863-1868; doi:10.1093/carcin/20.9.1863 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SHORT COMMUNICATIONS:

Ming Liu, Norbert M. Wikonkal, and Douglas E. Brash

Induction of cyclin-dependent kinase inhibitors and G₁ prolongation by the chemopreventive agent N-acetylcysteine
Carcinogenesis 1999 20: 1869-1872; doi:10.1093/carcin/20.9.1869 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Min Wei, Hideki Wanibuchi, Shinji Yamamoto, Wei Li, and Shoji Fukushima

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats
Carcinogenesis 1999 20: 1873-1876; doi:10.1093/carcin/20.9.1873 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Adeline Seow, Bin Zhao, Wee-Teng Poh, Ming Teh, Philip Eng, Yee-Tang Wang, Wan-Cheng Tan, Edmund J.D. Lee, and Hin-Peng Lee

NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore
Carcinogenesis 1999 20: 1877-1881; doi:10.1093/carcin/20.9.1877 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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