Carcinogenesis

COMMENTARY:

Silvio De Flora

Threshold mechanisms and site specificity in chromium(VI) carcinogenesis
Carcinogenesis 2000 21: 533-541; doi:10.1093/carcin/21.4.533 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ACCELERATED PAPERS:

Alison K. Bauer, Lori D. Dwyer-Nield, and Alvin M. Malkinson

High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors
Carcinogenesis 2000 21: 543-550; doi:10.1093/carcin/21.4.543 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ruth M. Lunn, Kathy J. Helzlsouer, Ram Parshad, David M. Umbach, Emily L. Harris, Katherine K. Sanford, and Douglas A. Bell

XPD polymorphisms: effects on DNA repair proficiency
Carcinogenesis 2000 21: 551-555; doi:10.1093/carcin/21.4.551 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CANCER BIOLOGY:

N. Rajeswari, Y.R. Ahuja, U. Malini, S. Chandrashekar, N. Balakrishna, K.V. Rao, and Ashok Khar

Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay
Carcinogenesis 2000 21: 557-561; doi:10.1093/carcin/21.4.557 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Valérie Robert, Pierre Michel, Jean Michel Flaman, Anne Chiron, Cosette Martin, Francoise Charbonnier, Bernard Paillot, and Thierry Frebourg

High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis
Carcinogenesis 2000 21: 563-565; doi:10.1093/carcin/21.4.563 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hairong Geng, Paul H. Naylor, Julie Dosescu, Magdalena Skunca, Adhip P.N. Majumdar, and Jeffrey A. Moshier

TGF is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase
Carcinogenesis 2000 21: 567-572; doi:10.1093/carcin/21.4.567 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Paul Finnon, Andrew R.J. Silver, and Simon D. Bouffler

Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription
Carcinogenesis 2000 21: 573-578; doi:10.1093/carcin/21.4.573 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sabina Cosulich, Neil James, and Ruth Roberts

Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators
Carcinogenesis 2000 21: 579-584; doi:10.1093/carcin/21.4.579 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katherine F. Roby, Christopher C. Taylor, Jeffrey P. Sweetwood, Ying Cheng, Judith L. Pace, Ossama Tawfik, Diane L. Persons, Peter G. Smith, and Paul F. Terranova

Development of a syngeneic mouse model for events related to ovarian cancer
Carcinogenesis 2000 21: 585-591; doi:10.1093/carcin/21.4.585 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neil J. Toft, Owen J. Sansom, Roger A. Brookes, Mark J. Arends, Michelle Wood, Geoffrey P. Margison, Douglas J. Winton, and Alan R. Clarke

In vivo administration of O⁶-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine
Carcinogenesis 2000 21: 593-598; doi:10.1093/carcin/21.4.593 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven Kazianis, Luis Della Coletta, Donald C. Morizot, Dennis A. Johnston, Elizabeth A. Osterndorff, and Rodney S. Nairn

Overexpression of a fish CDKN2 gene in a hereditary melanoma model
Carcinogenesis 2000 21: 599-605; doi:10.1093/carcin/21.4.599 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION:

Ralph J. Delfino, Rashmi Sinha, Cynthia Smith, John West, Edward White, Henry J. Lin, Shu-Yuan Liao, Jason S.Y. Gim, Hoang L. Ma, John Butler, and Hoda Anton-Culver

Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype
Carcinogenesis 2000 21: 607-615; doi:10.1093/carcin/21.4.607 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chinthalapally V. Rao, Indranie Cooma, Jose G.Rosa Rodriguez, Barbara Simi, Karam El-Bayoumy, and Bandaru S. Reddy

Chemoprevention of familial adenomatous polyposis development in the APC^min mouse model by 1,4-phenylene bis(methylene)selenocyanate
Carcinogenesis 2000 21: 617-621; doi:10.1093/carcin/21.4.617 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elisabete Weiderpass, Ingemar Persson, Håkan Melhus, Sara Wedrén, Andreas Kindmark, and John A. Baron

Estrogen receptor gene polymorphisms and endometrial cancer risk
Carcinogenesis 2000 21: 623-627; doi:10.1093/carcin/21.4.623 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Seung Jun Kwack and Byung Mu Lee

Correlation between DNA or protein adducts and benzo[a]pyrene diol epoxide I–triglyceride adduct detected in vitro and in vivo
Carcinogenesis 2000 21: 629-632; doi:10.1093/carcin/21.4.629 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maralee McVean, Hengyi Xiao, Ken-ichi Isobe, and Jill C. Pelling

Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes
Carcinogenesis 2000 21: 633-639; doi:10.1093/carcin/21.4.633 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Lezlee G. Coghlan, I. Gimenez-Conti, Heather E. Kleiner, Susan M. Fischer, Joyce E. Rundhaug, Claudio J. Conti, Thomas J. Slaga, and John DiGiovanni

Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis
Carcinogenesis 2000 21: 641-646; doi:10.1093/carcin/21.4.641 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard T. Miller, Steven P. Anderson, J.Christopher Corton, and Russell C. Cattley

Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas
Carcinogenesis 2000 21: 647-652; doi:10.1093/carcin/21.4.647 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiromi Sato, Hideko Sone, Masaru Sagai, Kazuo T. Suzuki, and Yasunobu Aoki

Increase in mutation frequency in lung of Big Blue^® rat by exposure to diesel exhaust
Carcinogenesis 2000 21: 653-661; doi:10.1093/carcin/21.4.653 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nils Homann, Jyrki Tillonen, Jukka H. Meurman, Hanna Rintamäki, Christian Lindqvist, Merja Rautio, Hannele Jousimies-Somer, and Mikko Salaspuro

Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer
Carcinogenesis 2000 21: 663-668; doi:10.1093/carcin/21.4.663 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anna-Karin Alexandrie, Margareta Warholm, Ulrica Carstensen, Anna Axmon, Lars Hagmar, Jan Olof Levin, Conny Östman, and Agneta Rannug

CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure
Carcinogenesis 2000 21: 669-676; doi:10.1093/carcin/21.4.669 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tamie Nakajima, Yuji Kamijo, Nobuteru Usuda, Yan Liang, Yoshimitsu Fukushima, Kiyokazu Kametani, Frank J. Gonzalez, and Toshifumi Aoyama

Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor (PPAR)
Carcinogenesis 2000 21: 677-682; doi:10.1093/carcin/21.4.677 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yuyang Christine Cai, Guang-yu Yang, Yan Nie, Li-Dong Wang, Xin Zhao, Yun-long Song, Darren N. Seril, Jie Liao, Eric Poe Xing, and Chung S. Yang

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53
Carcinogenesis 2000 21: 683-689; doi:10.1093/carcin/21.4.683 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katsumi Takaba, Koji Saeki, Kazuo Suzuki, Hideki Wanibuchi, and Shoji Fukushima

Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate
Carcinogenesis 2000 21: 691-700; doi:10.1093/carcin/21.4.691 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. Ramírez, L.M. Del Razo, M.C. Gutierrez-Ruíz, and M.E. Gonsebatt

Arsenite induces DNA–protein crosslinks and cytokeratin expression in the WRL-68 human hepatic cell line
Carcinogenesis 2000 21: 701-706; doi:10.1093/carcin/21.4.701 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Takako Ikeda, Akiyoshi Nishikawa, Takayoshi Imazawa, Shuichi Kimura, and Masao Hirose

Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia
Carcinogenesis 2000 21: 707-713; doi:10.1093/carcin/21.4.707 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Barbara S. Shane, Johan de Boer, David E. Watson, Joseph K. Haseman, Barry W. Glickman, and Kenneth R. Tindall

LacI mutation spectra following benzo[a]pyrene treatment of Big Blue^® mice
Carcinogenesis 2000 21: 715-725; doi:10.1093/carcin/21.4.715 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Haizhou Zhang, Lisa M. Kamendulis, Jiazhong Jiang, Yong Xu, and James E. Klaunig

Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells
Carcinogenesis 2000 21: 727-733; doi:10.1093/carcin/21.4.727 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Takeki Tsutsui, Yukiko Tamura, Makoto Hagiwara, Takashi Miyachi, Hirohito Hikiba, Chikahiro Kubo, and J.Carl Barrett

Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen
Carcinogenesis 2000 21: 735-740; doi:10.1093/carcin/21.4.735 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kandallu R. Kumaresan and Muriel W. Lambert

Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links
Carcinogenesis 2000 21: 741-751; doi:10.1093/carcin/21.4.741 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stéphan Ellmerich, Marie Schöller, Benoît Duranton, Francine Gossé, Michel Galluser, Jean-Paul Klein, and Francis Raul

Promotion of intestinal carcinogenesis by Streptococcus bovis
Carcinogenesis 2000 21: 753-756; doi:10.1093/carcin/21.4.753 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Harry S. Cooper, Sreekant Murthy, Kazuaki Kido, Hiraoki Yoshitake, and Anne Flanigan

Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation
Carcinogenesis 2000 21: 757-768; doi:10.1093/carcin/21.4.757 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gloria M. Calaf and Tom K. Hei

Establishment of a radiation- and estrogen-induced breast cancer model
Carcinogenesis 2000 21: 769-776; doi:10.1093/carcin/21.4.769 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yan Yang, Jagadeesan Nair, Alain Barbin, and Helmut Bartsch

Immunohistochemical detection of 1,N⁶-ethenodeoxyadenosine, a promutagenic DNA adduct, in liver of rats exposed to vinyl chloride or an iron overload
Carcinogenesis 2000 21: 777-781; doi:10.1093/carcin/21.4.777 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Samuel M. Cohen, Lora L. Arnold, Martin Cano, Masahiro Ito, Emily M. Garland, and R.Anthony Shaw

Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats
Carcinogenesis 2000 21: 783-792; doi:10.1093/carcin/21.4.783 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Philip Carthew, Richard E. Edwards, Barbara M. Nolan, Elizabeth A. Martin, Robert T. Heydon, Ian N.H. White, and Mary J. Tucker

Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia
Carcinogenesis 2000 21: 793-797; doi:10.1093/carcin/21.4.793 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Francis L.Martin, Kathleen J.Cole, David Harvey, Gillian Weaver, J.Andrew Williams, Barbara C.Millar, David H.Phillips, and Philip L.Grover

DNA damage in human breast milk cells and its induction by ‘early’ and ‘late’ milk extracts
Carcinogenesis 2000 21: 799-804; doi:10.1093/carcin/21.4.799 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Najima Baou, Mourad Bouras, Jean-Pierre Droz, Mohamed Benahmed, and Slavica Krantic

Evidence for a selective loss of somatostatin receptor subtype expression in male germ cell tumors of seminoma type
Carcinogenesis 2000 21: 805-810; doi:10.1093/carcin/21.4.805 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SHORT COMMUNICATIONS:

Jifu Zhao, Moushumi Lahiri-Chatterjee, Yogesh Sharma, and Rajesh Agarwal

Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin
Carcinogenesis 2000 21: 811-816; doi:10.1093/carcin/21.4.811 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bárbara Meléndez, Marcos Malumbres, Ignacio Pérez de Castro, Javier Santos, Angel Pellicer, and José Fernández-Piqueras

Characterization of the murine p19^ARF promoter CpG island and its methylation pattern in primary lymphomas
Carcinogenesis 2000 21: 817-821; doi:10.1093/carcin/21.4.817 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey M. Peters, Ivan Rusyn, Michelle L. Rose, Frank J. Gonzalez, and Ronald G. Thurman

Peroxisome proliferator-activated receptor is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis
Carcinogenesis 2000 21: 823-826; doi:10.1093/carcin/21.4.823 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ahmed El-Sohemy and Michael C. Archer

Inhibition of N-methyl-N-nitrosourea- and 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis by dietary cholesterol is independent of Ha-ras mutations
Carcinogenesis 2000 21: 827-831; doi:10.1093/carcin/21.4.827 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xiusheng Qin, Darryl Shibata, and Stanton L. Gerson

Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea
Carcinogenesis 2000 21: 833-838; doi:10.1093/carcin/21.4.833 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven G. Carmella, Edward J. McIntee, Menglan Chen, and Stephen S. Hecht

Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco
Carcinogenesis 2000 21: 839-843; doi:10.1093/carcin/21.4.839 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Helmut Bartsch, David H. Phillips, Jagadeesan Nair, Alan Hewer, Gabriele Meyberg-Solomeyer, and Eva-Maria Grischke

Lack of evidence for tamoxifen– and toremifene–DNA adducts in lymphocytes of treated patients
Carcinogenesis 2000 21: 845-847; doi:10.1093/carcin/21.4.845 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Frederica Perera, Wei Yann Tsai, Christopher Dickey, and Kari Hemminki

Re: Hemminki,K., Dickey,C., Karlsson,S., Bell,D., Hsu,Y., Tsai,W.-Y., Mooney,L.A., Savela,K. and Perera,F.P. (1997) Aromatic DNA adducts in foundry workers in relation to exposure, lifestyle and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis, 18, 345–350
Carcinogenesis 2000 21: 849; doi:10.1093/carcin/21.4.849 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

CORRIGENDUM:

Stephen S. Hecht, Thomas E. Spratt, and Neil Trushin

Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Carcinogenesis 2000 21: 850. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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