Carcinogenesis

COMMENTARY:

B. Singer and B. Hang

Nucleic acid sequence and repair: role of adduct, neighbor bases and enzyme specificity
Carcinogenesis 2000 21: 1071-1078; doi:10.1093/carcin/21.6.1071 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

CANCER BIOLOGY:

Motoaki Hanzawa, Masanobu Shindoh, Fumihiro Higashino, Motoaki Yasuda, Nobuo Inoue, Kyoko Hida, Mitsunobu Ono, Takao Kohgo, Motoyasu Nakamura, Ken-ichi Notani, Hiroshi Fukuda, Yasunori Totsuka, Koichi Yoshida, and Kei Fujinaga

Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes
Carcinogenesis 2000 21: 1079-1085; doi:10.1093/carcin/21.6.1079 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Corinne Petit-Frère, Emily Capulas, Debbie A. Lyon, Christopher J. Norbury, Jillian E. Lowe, Peter H. Clingen, Enriqueta Riballo, Michael H. L. Green, and Colin F. Arlett

Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes
Carcinogenesis 2000 21: 1087-1095; doi:10.1093/carcin/21.6.1087 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy J. King, Laurie H. Fukushima, A. David Hieber, Kelly A. Shimabukuro, Wael A. Sakr, and John S. Bertram

Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression
Carcinogenesis 2000 21: 1097-1109; doi:10.1093/carcin/21.6.1097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. Obst, S. Wagner, K.F. Sewing, and W. Beil

Helicobacter pylori causes DNA damage in gastric epithelial cells
Carcinogenesis 2000 21: 1111-1115; doi:10.1093/carcin/21.6.1111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mami Takahashi, Seiichi Nakatsugi, Takashi Sugimura, and Keiji Wakabayashi

Frequent mutations of the ß-catenin gene in mouse colon tumors induced by azoxymethane
Carcinogenesis 2000 21: 1117-1120; doi:10.1093/carcin/21.6.1117 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bruno M. Schmied, Alexis B. Ulrich, Hosei Matsuzaki, Tarek H. El-Metwally, Xianzhong Ding, Mirabella E. Fernandes, Thomas E. Adrian, William G. Chaney, Surinder K. Batra, and Parviz M. Pour

Biologic instability of pancreatic cancer xenografts in the nude mouse
Carcinogenesis 2000 21: 1121-1127; doi:10.1093/carcin/21.6.1121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lyn M. Knowles and John A. Milner

Diallyl disulfide inhibits p34^cdc2 kinase activity through changes in complex formation and phosphorylation
Carcinogenesis 2000 21: 1129-1134; doi:10.1093/carcin/21.6.1129 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Enrico Cappelli, Paolo Degan, and Guido Frosina

Comparative repair of the endogenous lesions 8-oxo-7,8-dihydroguanine (8-oxoG), uracil and abasic site by mammalian cell extracts: 8-oxoG is poorly repaired by human cell extracts
Carcinogenesis 2000 21: 1135-1141; doi:10.1093/carcin/21.6.1135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION:

Gianpiero Romano, Alessandro Sgambato, Rita Mancini, Giovanni Capelli, Maria Rosaria Giovagnoli, Giovanna Flamini, Alma Boninsegna, Aldo Vecchione, and Achille Cittadini

8-Hydroxy-2'-deoxyguanosine in cervical cells: correlation with grade of dysplasia and human papillomavirus infection
Carcinogenesis 2000 21: 1143-1147; doi:10.1093/carcin/21.6.1143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael J. Wargovich, Arnaldo Jimenez, Kathy McKee, Vernon E. Steele, Marco Velasco, Johnnie Woods, Roger Price, Kenneth Gray, and Gary J. Kelloff

Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression
Carcinogenesis 2000 21: 1149-1155; doi:10.1093/carcin/21.6.1149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Johanna W. Lampe, Irena B. King, Sue Li, Margaret T. Grate, Karen V. Barale, Chu Chen, Ziding Feng, and John D. Potter

Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets
Carcinogenesis 2000 21: 1157-1162; doi:10.1093/carcin/21.6.1157 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew B. Schabath, Margaret R. Spitz, Xinmei Zhang, George L. Delclos, and Xifeng Wu

Genetic variants of myeloperoxidase and lung cancer risk
Carcinogenesis 2000 21: 1163-1166; doi:10.1093/carcin/21.6.1163 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marja Mutanen, Anne-Maria Pajari, and Seija I. Oikarinen

Beef induces and rye bran prevents the formation of intestinal polyps in Apc^Min mice: relation to ß-catenin and PKC isozymes
Carcinogenesis 2000 21: 1167-1173; doi:10.1093/carcin/21.6.1167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yuesheng Zhang

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
Carcinogenesis 2000 21: 1175-1182; doi:10.1093/carcin/21.6.1175 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Takuji Tanaka, Hiroyuki Kohno, Reona Shimada, Seiko Kagami, Fumio Yamaguchi, Shigehiro Kataoka, Toshiaki Ariga, Akira Murakami, Koich Koshimizu, and Hajime Ohigashi

Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats
Carcinogenesis 2000 21: 1183-1189; doi:10.1093/carcin/21.6.1183 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Budiawan and Erwin Eder

Detection of 1,N²-propanodeoxyguanosine adducts in DNA of Fischer 344 rats by an adapted ³²P-post-labeling technique after per os application of crotonaldehyde
Carcinogenesis 2000 21: 1191-1196; doi:10.1093/carcin/21.6.1191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Henrik Frandsen and Jan Alexander

N-acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of 2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Carcinogenesis 2000 21: 1197-1203; doi:10.1093/carcin/21.6.1197 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jinqiang Chen, Mamata Gokhale, Brian Schofield, Shelly Odwin, and James D. Yager

Inhibition of TGF-ß-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes
Carcinogenesis 2000 21: 1205-1211; doi:10.1093/carcin/21.6.1205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cynthia Agus, Kenneth F. Ilett, Fred F. Kadlubar, and Rodney F. Minchin

Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline
Carcinogenesis 2000 21: 1213-1219; doi:10.1093/carcin/21.6.1213 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Raheel M. Ansari and Tom K. Hei

Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells
Carcinogenesis 2000 21: 1221-1226; doi:10.1093/carcin/21.6.1221 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hirotaka Kushida, Ken-ichi Fujita, Akihiro Suzuki, Masami Yamada, Toru Endo, Takehiko Nohmi, and Tetsuya Kamataki

Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase
Carcinogenesis 2000 21: 1227-1232; doi:10.1093/carcin/21.6.1227 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pramod Upadhyaya, Steven G. Carmella, F.Peter Guengerich, and Stephen S. Hecht

Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues
Carcinogenesis 2000 21: 1233-1238; doi:10.1093/carcin/21.6.1233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stimson P. Schantz, Qiang Huang, Kinner Shah, V.V.V.S. Murty, T.C. Hsu, Guopei Yu, Peter E. Andersen, Andrew G. Huvos, and Raju S.K. Chaganti

Mutagen sensitivity and environmental exposures as contributing causes of chromosome 3p losses in head and neck cancers
Carcinogenesis 2000 21: 1239-1246; doi:10.1093/carcin/21.6.1239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Beatrice L. Pool-Zobel, Herman Adlercreutz, Michael Glei, Ute M. Liegibel, Julie Sittlingon, Ian Rowland, Kristiina Wähälä, and Gerhard Rechkemmer

Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells
Carcinogenesis 2000 21: 1247-1252; doi:10.1093/carcin/21.6.1247 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SHORT COMMUNICATIONS:

Stephen Nesnow, Christine Davis, William T. Padgett, Linda Adams, Michele Yacopucci, and Leon C. King

8,9-Dihydroxy-8,9-dihydrodibenzo[a,l]pyrene is a potent morphological cell-transforming agent in C3H10T¹/₂Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts
Carcinogenesis 2000 21: 1253-1257; doi:10.1093/carcin/21.6.1253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Agnes Baross-Francis, M.Kate Milhausen, Susan E. Andrew, Gareth Jevon, and Frank R. Jirik

Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene
Carcinogenesis 2000 21: 1259-1262; doi:10.1093/carcin/21.6.1259 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Fumio Ide, Naoko Iida, Yoko Nakatsuru, Hideaki Oda, Kiyoji Tanaka, and Takatoshi Ishikawa

Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors
Carcinogenesis 2000 21: 1263-1265; doi:10.1093/carcin/21.6.1263 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CORRIGENDUM:

Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells
Carcinogenesis 2000 21: 1267. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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